Shanshan Chen

As a collaborative biostatistician, I have worked on various clinical studies where I advocated and actively applied more advantageous models, and multiple biomedical studies where I advocated for standardized analysis (e.g. quantifying westner blots, Oil Red O staining, and immunohistochemistry images) as well as more rigorous methods beyond widely-adopted analysis in biomedical studies (e.g. t-tests, change-score analysis, and ratio normalization). These advanced and rigorous methods have greatly helped bench scientists understand their data with reliable and reproducible evidence.

Examples of collaborative research:

- Modeling of Six-Minute Walk Trajectory in Multiple Sclerosis paper

- Walk Capcity and Physical Activity Levels in Pediatric-Onset Multiple Sclerosis paper

- Keto-diet in Multiple Sclerosis paper

- Sleep Metrics in Childhood Obesity paper

- Effect of Thyroid Liothyroine on Cardiovascular and Metabolic System (a Pharmacodynamic Study) paper

- Gait Analysis for Diabetic Peripeheral Neuropathy paper

- Sex-selective Role of Angiopoietin-2 in Obesity and Metabolic Syndrome paper

In this project, we have investigated the role of Angiopoietin-2 in adipose tissue in combating obesity. 
We found that this link is only significant in females, both in mice and a large human subjects cohort. 
Interestingly, serum levels of Angiopoietin-2 in pre-and post-menopausal women are also significantly different. 
This led us to examine the role of estrogen in Angiopoietin-2 transcription regulation in adipocytes, 
and indeed Angiopoietin-2 is upregulated by estradiol.  

- Chamber Music: Movement and Muscle Activity during Violin Playing